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Missionsupporting

The Bus Assassination

Franklin drives a city bus along its route to locate and eliminate investor Isaac Penny.

RoleStory mission guide
Importancesupporting
  • ModeStory Mode
  • TypeOptional mission
  • Difficultyeasy
  • Walkthrough steps6

Time and medal conditions vary by route, approach, player count, replay state, and game version.

Key takeaways

Prepare before the opening marker and treat each objective update as a checkpoint.

  • Primary goal Franklin drives a city bus along its route to locate and eliminate investor Isaac Penny.
  • Protect mission-critical assets Avoid unnecessary vehicle damage, friendly fire, or abandoning a required target outside the objective radius.
  • Use protagonist abilities Use Franklin for precision driving, Michael for controlled gunfights, and Trevor for high-damage combat whenever the mission makes them available.
  • Do not rush the final marker Clear pursuit conditions and keep required characters or vehicles together before entering extraction.

Overview

Franklin drives a city bus along its route to locate and eliminate investor Isaac Penny.

Franklin drives a city bus along its route to locate and eliminate investor Isaac Penny.

This Story Mode mission advances the protagonists’ connected storyline. Some neighboring missions can become available simultaneously, so the exact play order may vary.

The walkthrough below separates travel, setup, combat, pursuit, and extraction checkpoints so a failed section can be diagnosed without repeating the same mistake.

Characters in this mission

Where this sits

PreparationTravel to the bus depot and take the assigned bus
Core objectivePursue him when he flees by bicycle
CompletionLeave the bus and clear any police attention
  1. 1The Vice AssassinationpreviousPrevious
  2. ●The Bus AssassinationcurrentCurrent guide
  3. 3The Construction AssassinationnextNext

Branching heist preparations and simultaneous character missions can alter the playable order.

Requirements and recommended loadout

Enter with mission-appropriate ammunition, armor, and a vehicle that can survive the opening travel phase.

  • RequiredComplete the preceding story unlocks
  • RecommendedFull body armor and stocked ammunitionParticularly valuable for missions marked moderate or hard.
  • RecommendedAccurate mid-range weaponA rifle or stable automatic weapon handles most outdoor gunfights.
  • OptionalClose-range backupUseful inside buildings, alleys, and vehicles.
  • RecommendedSave the relevant protagonist abilityUse it for the most difficult chase, driving, or combat checkpoint.

Objectives

  1. Travel to the bus depot and take the assigned bus
  2. Follow the marked route and stop for passengers
  3. Continue until Isaac Penny is identified
  4. Pursue him when he flees by bicycle
  5. Eliminate the target
  6. Leave the bus and clear any police attention

Detailed walkthrough

  1. 01

    Travel to the bus depot and take the assigned bus

    Travel to the bus depot and take the assigned bus

    Travel to the bus depot and take the assigned bus. Approach from the safest side, clear immediate threats, and wait for the possession or collection confirmation before moving to extraction. Once the checkpoint registers, immediately orient toward the next marked objective.

    TipBefore triggering the opening marker, restock armor and ammunition if the mission is expected to involve combat.

    Checkpoint
  2. 02

    Follow the marked route and stop for passengers

    Follow the marked route and stop for passengers

    Follow the marked route and stop for passengers. Use the minimap to anticipate turns, preserve the mission vehicle, and prioritize keeping visual contact over risky shortcuts. Once the checkpoint registers, immediately orient toward the next marked objective.

    Checkpoint
  3. 03

    Continue until Isaac Penny is identified

    Continue until Isaac Penny is identified

    Continue until Isaac Penny is identified. Follow the marked route and wait for the objective prompt to update before leaving the area. Once the checkpoint registers, immediately orient toward the next marked objective.

  4. 04

    Pursue him when he flees by bicycle

    Pursue him when he flees by bicycle

    Pursue him when he flees by bicycle. Use the minimap to anticipate turns, preserve the mission vehicle, and prioritize keeping visual contact over risky shortcuts. Once the checkpoint registers, immediately orient toward the next marked objective.

    Checkpoint
  5. 05

    Eliminate the target

    Eliminate the target

    Eliminate the target. Move from cover to cover, remove exposed or elevated shooters first, and do not advance until the current flank is secure. Once the checkpoint registers, immediately orient toward the next marked objective.

  6. 06

    Leave the bus and clear any police attention

    Leave the bus and clear any police attention

    Leave the bus and clear any police attention. Move from cover to cover, remove exposed or elevated shooters first, and do not advance until the current flank is secure. Remain in the final marker until the mission-complete transition begins.

    Watch outA failed push can expose the mission vehicle or protagonist to concentrated damage; reset behind cover instead of forcing progress.

    Checkpoint

Difficult sections and useful strategies

Strengths

  • Frequent objective markers make the intended route readable
  • Character switching or team roles can divide pressure
  • Most combat checkpoints provide cover or a defensible angle

Weaknesses

  • Mission-critical vehicles and allies can fail the attempt
  • Police or enemy reinforcements punish slow extraction
  • Long pursuits can be lost by overcommitting to shortcuts

Best uses

  • Clear enemies from range before moving a required vehicle
  • Use special abilities during the hardest driving or combat segment
  • Restart from the latest checkpoint after a failed gold-medal attempt rather than improvising a damaged route

Completion checklist

  • Travel to the bus depot and take the assigned busCheckpoint 1
  • Follow the marked route and stop for passengersCheckpoint 2
  • Continue until Isaac Penny is identifiedCheckpoint 3
  • Pursue him when he flees by bicycleCheckpoint 4
  • Eliminate the targetCheckpoint 5
  • Leave the bus and clear any police attentionFinal completion condition

Failure conditions and checkpoints

  • A required protagonist, ally, or protected target dies.Restart from the most recent mission checkpoint.
  • A mission-critical vehicle is destroyed, abandoned, or leaves the playable route.Use the restart option rather than continuing in an unmarked replacement.
  • The target escapes or a timed objective expires.Prioritize route discipline and the primary objective over optional combat.
  • The player is wasted or all shared team lives are exhausted.Story Mode reloads the latest checkpoint.

On failure

Major travel, combat, and transition phases generally create checkpoints, but exact restart placement can vary by approach and replay mode.

Rewards and aftermath

  • Mission completion and progression
    Unlocks the next related story activity, contact, property, or preparation where applicable.

Sources and verification